Pediatric allergic subseptic syndrome

Allergic subseptic syndrome is also called Wissler-Fanconi syndrome, Wissler syndrome, subacute allergic fever and so on. It is a rare infection-allergy syndrome mainly characterized by long-term intermittent persistent fever, rash, joint pain, leukocytosis, and negative blood culture. Many people consider that the clinical manifestations, laboratory tests, and development of the disease are similar to juvenile rheumatoid arthritis, so they are considered to be a clinical type or a clinical stage of systemic rheumatoid arthritis, not a unique disease. It is also believed that it is an allergic disease between rheumatic fever and rheumatoid disease, which is related to autoimmunity.