Belladonna plant drug poisoning

Atropine is an alkaloid extracted from belladonna, mandala, sedge and other plants, and its commonly used is its sulfate. The main alkaloids in belladonna are atropine and scopolamine. Datura is the golden flower, its roots, stems, leaves, flowers and fruits contain atropine, scopolamine, scopolamine, etc .; the atropine content in the fruit can reach 8.33%. The alkaloids contained in the sedge rhizomes are mainly scopolamine, atropine and scopolamine. This class of drugs is rapidly absorbed through the gastrointestinal tract, and the local mucosa can be inhaled, and most of them are hydrolyzed by liver enzymes to destroy them. Within 24 hours, 4/5 of atropine is excreted in the body, while scopolamine is excreted more slowly. Belladonna alkaloids are drugs for the anticholinergic response system and can block many of the responses caused by cholinergic fibers. Atropine can slightly excite the high-level nerve centers, hypothalamus, and medulla, especially motor and speech functions, but large doses of the central nervous system from excitement to inhibition. The therapeutic dose of scopolamine has a tranquilizing effect, but excites the respiratory center. Atropine can fight vasodilation and blood pressure drop caused by choline drugs. Atropine and scopolamine strongly inhibit the secretion of sweat glands, salivary glands, lacrimal glands, and bronchial glands; make iris sphincter and ciliary muscles ineffective on cholinergic nerves, causing pupil dilation and elevated intraocular pressure.