Histiocytosis

Histiocytosis (reticulosis) refers to a group of diseases in which histiocytic tumors or pseudotumorous hyperplasia cannot be classified as malignant lymphoma. Generally includes bone eosinophilic granuloma, xanthomatosis, and malignant reticulocyte proliferation in infants. The three should be regarded as chronic and acute processes of the same lesion, and there can be transitional and intermediate types. Due to different stages of development, lesions can be single or multiple, and can be located inside or outside the bone. Histiocytosis, including all its variants, is a systemic disorder. These kinds of performance should be said to be more appropriate syndromes, although they are different from each other, but the boundaries are not very clear. Many authors at home and abroad have reported that eosinophilic granulomas have turned into yellow tumors. Histiocytosis can be divided into single and multiple. The former is bone eosinophilic granuloma, and the latter is divided into chronic type (with or without xanthomatosis) and intermediate type (transitional type) for acute type (malignant reticulocyte proliferation in children). Some authors divide histiocytosis into localized and diffuse types, the former mostly occurring in older children and adults, and the latter more common in infants. There are many male patients with eosinophilic granuloma, and the common age of onset is 1 to 15 years, especially between 5 to 10 years. But it can also happen in adulthood. Eosinophilic granuloma usually occurs in the ribs and mandibles in people over 20 years of age, and in the skull below 20 years of age. Occurs rarely in the spine.