Primary myelofibrosis in the elderly

Myelofibrosis (MF) is a myeloproliferative disease that manifests as diffuse fibrous tissue hyperplasia of the bone marrow, often accompanied by extramedullary hematopoiesis, mainly in the spleen, followed by the liver and lymph nodes. The typical clinical manifestations are promyelocytic-erythrocytic anemia, marked enlargement of the spleen, and varying degrees of osteosclerosis. MF has two categories: primary and secondary. There are obvious reasons for secondary MF, mainly including CML, MDS, lymphoma, bone marrow metastatic cancer, and diffuse tuberculosis. The etiology of primary MF is unknown.