Pediatric pure red cell aplastic anemia

Pure red cell aplasia (PRCA) has only developmental disorders of the red blood cell system, and there is no change in white blood cells and platelets. Immature red blood cells in the bone marrow stop at the stage of directional stem cells and early immature red blood cells. Other immature red blood cells are extremely reduced, but the granulocyte system and megakaryocytes develop normally, and the life span of red blood cells is slightly shorter than normal. Anemia is positively pigmented, and reticulocytes are reduced or absent. Pediatric disease is more common than adults, and the disease type and prognosis are different from adults. In 1936, Jaseph first reported a kind of pure red aplastic disorder in children, which was considered to be congenital or inherited. Diamond and Blackfan described this disease as an independent disease in 1938, so it was also called Diamond-Blackfan anemia.