Pediatric tuberous sclerosis syndrome

Tuberous sclerosis, also known as tuberous sclerosis, is also known as Bourneville syndrome, Pringle syndrome, Bourneville-Pringle maternal plaque, and facial symmetric vasodilating fibroma macular plaque (naevus fibromatous angiectodes symmetricus faciei) Etc., is a type of neurocutaneous syndrome. With the application of molecular biology technology, the understanding of the disease has further improved. At present, it is considered to be a systemic disease characterized by multi-organ tissue defects and hamartomas, except for peripheral nerves, skeletal muscles, and pineal cones, which can be involved in vitro. All tissues and organs. Clinically, it is characterized by symmetrical facial papules, epileptic seizures, mental retardation, nervous system and retinal abnormalities in childhood. According to reports in the literature, the incidence of this disease is about 1 in 100,000 to 3 in 100,000. The prevalence of male and female is about 1: 1 to 3: 1.