Hilde

Hilde's disease, also known as diffuse sclerosis, is a subacute or chronic extensive white matter demyelinating disease. Schilder (1912) was first reported as encephalitis periaxialis diffusa, hence the name Hilde's disease. The term diffuse sclerosis was first used by Strumpell to describe the hard texture of fresh brains from patients with alcoholism, and it was later used for diffuse glial hyperplasia for any reason. In 1912, Schilder described a 14-year-old girl with progressive mental retardation with increased intracranial pressure who died after 19 weeks. Autopsy revealed large white matter on both sides of the cerebral hemisphere, well-defined demyelination areas, and many small demyelination lesions similar to those of ordinary MS.