Hemochromatotic osteoarthropathy

This disease is caused by abnormal iron metabolism, which causes excessive iron content in the body, and is deposited in various internal organs and organs to produce various symptoms. It is clinically divided into two types: spontaneous and secondary. The former is due to hereditary iron metabolism disorders, which is characterized by excessive iron absorption, which results in pathological iron deposits, and eventually results in dysfunction of many organs, most notably liver, pancreas, heart, and pituitary. Its typical clinical manifestations are hepatomegaly, diabetes, skin pigmentation, and sexual dysfunction. Some cases may be manifested by general weakness, weight loss, abdominal pain, dyspnea and edema. Secondary hemochromatosis is mostly secondary to long-term repeated massive blood transfusions (such as the number of blood transfusions can reach more than 100 times in the treatment of aplastic anemia) and in the case of previous iron treatment. Can also be seen in hemolytic disease, malnutrition, vitamin A deficiency and long-term diarrhea. In normal people, the total iron content in the body is 3 to 5 g. When iron metabolism is impaired, it may accumulate more than 25g. 500mg of iron per 1000ml of whole blood during blood transfusion. It is generally believed that when the input iron exceeds 20g, secondary hemochromatosis is about to occur.