Lambert-Eaton syndrome

Lambert-Eaton syndrome, also known as myasthenic syndrome, is a special type of myasthenia and an autoimmune disease involving cholinergic synapses. First described by Lambert, Eaton, and Rooke (1956), the disease is characterized by weakness and fatigue of the proximal muscles of the limbs. The muscle strength of the affected muscle is strengthened after a brief contraction of the limb, and pathological fatigue occurs after continuous contraction. Lambert-Eaton syndrome is a neuromuscular junction disorder, which is caused by anti-P / Q-type voltage-gated calcium channel (P / Q-type VGCC) antibodies that cause calcium at the presynaptic membrane. The loss of the channel reduces the number of acetylcholine release units in the presynaptic membrane and causes muscle weakness.