Chronic granulomatosis in children

Pediatric chronic granulomatous disease is a lethal genetic defect in leukocytes. The main clinical feature is that, for some reason, the lack of NADPH oxidase in phagocytes leads to a decrease in the production of reactive oxygen species and H2O2 produced by the host phagocyte system and a deficiency in bactericidal function. Patients are highly sensitive to various catalase-positive bacteria, such as Staphylococcus, Serratia, Aspergillus, etc., and chronic bacterial infections occur repeatedly. Chronic granulomas are formed locally in the infection. The skin, lungs and lymph nodes are extensively granulomatous. Damage is characteristic.