Secondary cutaneous follicular center cell lymphoma

According to statistics from the United States NCI, there are 392 FCCLs in 1175 NHL cases, accounting for 34%. China's Shanghai Lymphoma Collaborative Group reported 115 of the 1771 cases of NHL (1972-198), accounting for only 6.5%, which is relatively rare and may be related to missed diagnosis. FCCL most commonly occurs in lymph nodes, but can also occur outside the nodes, such as the spleen, gastrointestinal tract, bone marrow, tonsils, and skin. Occurs in middle-aged and elderly people, and is more common in men. About 4% of systemic FCCLs are secondary to CML. FCCC is more common in small fissure cells, with 259 (68.2%) of 392 NCI cases. Of the 115 patients in the Shanghai Lymphoma Collaboration Group, 55 (59.8%) were followed, followed by 22 (24%) with mixed cellularity, 10 (11%) with large dehiscence, and 5 (5.4%) with non-splitting . Although the large-cell nature of FCCL is moderately malignant, it is generally low-grade. The prognosis of small fissure cells is good, and the 5-year survival rate is 70%. The 5-year survival rates of mixed cells and large cells are 50% and 45%, respectively. Subtypes of secondary cutaneous follicular central cell lymphoma, according to Burg statistics, centrocytic cell (CC), centroblastnic / centrocytic cell (CB / CC), and CB account for 8%, 3% to 6%, and 2.5% to 4% of CML. We have seen 18 cases, of which 9 were CB / CC, 7 were CC, and 2 were CB. 1. Centrocytic lymphoma This disease is also called lymphocytic sarcoma, which is a malignant lymphoma with small cleaved follicular center cells. 2. Centroblastic-centrocytic lymphoma (Centroblastic-centrocytic lymphoma) This disease is also known as Brill-Symmer disease, with malignant lyrephoma with small cleaved and large noncleaved follicular center eells), mixed small cleaved and large cell malignant lymohoma. 3. Centroblastic lymphoma This disease is also called malignant lymphoma with large non-cleaved follicular center cells. This disease is extremely rare. We saw 2 cases. It accounted for 1.0% of skin NHL in the same period. One male and one female. Onset ages were 28 and 33 years. Skin damage is the same as CC. One face tumor was accompanied by local parenchymal swelling, and normal hemoglobin anemia was also seen at first diagnosis. Patients with advanced lymph nodes, enlarged liver and spleen, died within 4 to 5 months after diagnosis.