Pediatric congenital anemia of erythropoiesis

Congenital dyserythropoietic anaemia (CDA), also known as congenital dyserythropoiesis, is a rare autosomal hereditary disease characterized by anemia with reduced reticulocytes and ineffective red blood cells. Patients often have enlarged liver and spleen, shortened red blood cell life, jaundice, and gallstones. The characteristics of CDA are: ① ineffective hematopoiesis (red blood cells and young red blood cells are destroyed in the bone marrow); ② there are more multinucleated red blood cells in the bone marrow; ③ secondary hemochromatosis.