Niacin deficiency in children

Nicotinic acid deficiency is also known as rickets disease, or pellagra (Italian translation, meaning rough skin). It is due to the lack of niacin (commonly known as vitamin PP) or nicotinamide in the body, and the disease mainly manifests as rash, digestive system and nervous system. In ancient China, it was called 黍 癞. As early as the eighteenth century, the clinical manifestations of the disease were described in detail, but it was not until 1917 that Goldberger confirmed that the disease was related to dietary factors. In 1937, nicotinic acid was used to treat human pellagra. Obvious results were obtained. It was discovered in 1945 that treatment with tryptophan had the same effect. Nicotinic acid and nicotinamide form the coenzyme system required for cellular respiration in the body. Niacin is a heat-resistant and alkali-resistant water-soluble vitamin. It is the most stable of all vitamins.