Pediatric phosphatase

Hypophosphatasia in children is a rare autosomal recessive hereditary disease, and a few are dominant. It mostly occurs in children, and is characterized by low or disappearance of alkaline phosphatase activity in blood, liver, bone, and kidney tissues, insufficiency of ossification, easy fractures and increased excretion of phosphorylthanolamine in urine. This disease was named in 1948 by a detailed review of Rathbun, also known as Rathbun syndrome, which is rare in clinical practice.