Serum γ-glutamyl transpeptidase)

r-glutamyl transpeptidase (r-GT) is found in kidney, pancreas, liver, spleen, intestine, brain, lung, skeletal muscle, and myocardial tissues. It is most abundant in the kidneys, followed by pancreas and liver. It is the most abundant in the liver. It is mainly distributed in the hepatocyte cytoplasm and intrahepatic bile duct epithelium, and γ-GT in normal human serum mainly comes from the liver. The normal value is 3 to 50 μ / L (γ-glutamyl-p-nitrobenzylamine method). This enzyme is only mildly and moderately elevated in acute hepatitis, chronic active hepatitis, and cirrhosis. However, in obstructive jaundice, this enzyme flows back into the blood due to excretory disorders. In the case of primary liver cancer, this enzyme is highly synthesized in the liver, which can cause a significant increase in transpeptidase in the blood, even more than 10 times normal. Alcoholism also significantly increased ν-GT, which is helpful for the diagnosis of alcoholic liver disease. In acute hepatitis, ν-GT decreases to normal later than transaminase, such as ν-GT continues to increase, suggesting a transition to chronic liver disease. Chronic liver disease, especially in cirrhosis, a persistently low value of v-GT indicates a poor prognosis. ν-GT is also used to diagnose liver metastases in malignant tumors.