Urinary α1 microglobulin

α1-microglobulin is a glycoprotein that is mainly synthesized in the liver and lymph tissues and is widely distributed on the surface of body fluids and lymphocyte membranes. There are two types of urinary α1-MG: free and bound. The free form can be filtered by the renal tubules, and the combined form cannot pass through the renal tubules. Pathological increase is seen in renal tubular damage, such as chronic renal failure, etc., and a combined type appears in the urine. α1-MG suggested that the glomerular filtration membrane was damaged. Urine α1-MG can be used as an early sensitive indicator of translational kidney injury.