POEMS syndrome

POEMS syndrome is a rare multisystem disease with unclear etiology and pathogenesis, mainly manifested as polyneuropathy (P), organomegaly (o), endocrinopathy (E), Monoclonal gammopathy (M, also called M-protein) and skin changes (S). The disease was first described by Crow in 1956 and later by Fukuse in 1968. Nakanishi et al. Called it Crow-Fukase syndrome. Takatsuki first identified and fully described the disease, so it is also called Takatsuki syndrome. Bardwick et al combined the first letters of the five main manifestations as POEMS syndrome. Patients with POEMS syndrome are often accompanied by osteosclerotic bone damage, malignant plasma cells can be seen on biopsy, and therefore belong to a special type of plasma cell disease. POEMS syndrome may be a paraneoplastic syndrome.