p16 gene

The P16 gene, also called MTS (multiple tumor suppressor 1) gene, is a new anti-cancer gene discovered by Kamb et al. Of Cold Spring Laboratory in the United States in 1994. It is a basic gene in the cell cycle and directly participates in cell cycle regulation and negative regulation. Cell proliferation and division. Homozygous deletions and mutations were found in 50% of human tumor cell lines. P16 is considered to be a new type of anticancer gene more important than P53. The product encoded by the P16 gene is a 16KD protein, that is, the P16 protein, which is located in the nucleus of the cell. The P16 protein is an inhibitor of CDK4 that acts on one of the key enzymes of the Cell Division Cycle. If its expression fails, it will lead to malignant proliferation of cells, leading to the occurrence of malignant tumors.