Tissue plasminogen activator
Tissue plasminogen activator is a single-chain glycoprotein that is mainly synthesized and secreted by vascular endothelial cells. It is continuously released into the blood and is widely present in various tissues of the body. The liver is inactivated by tissue plasminogen Main place. It has a high affinity for fibrin and then turns tyrosine plasminogen into plasmin. Degrades fibrin (pro) and some clotting factors. It is the key substance of fibrinolytic system.
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