Peyronie's disease

Penile fibrous cavernositis (hereinafter referred to as Peyronie disease) is a fibrotic lesion between the cavernous body of the penis and the white membrane. Single or several lesions appear on the cavernous body of the penis. Francois de La Peyronie described the characteristics of fibrous penile cavernitis in his dissertation in 1743 and was therefore named Peyronie disease. Peyronie disease is also known as penile sclerosis, penile fibromatosis, and scleroderma. The disease is characterized by damage to the white membrane of the cavernous body of the penis. During the erection, the penis is bent to the damaged side, which may be related to multiple minor penile injuries, but the exact cause is unknown. The lesion was located in the honeycomb connective tissue between the cavernous body of the penis and the white membrane. In the early stage of the microscope, lymphocytes and plasma cells infiltrated around the blood vessels of the connective tissue layer, and then collagen-based plaques were formed near the corpus cavernosum.