Hemangioendothelioma

Primary bone malignant hemangioendothelioma, also called angiosarcoma or hemangioendothelioma, is extremely rare. It was first reported by Kokodny in 1926. By 1971, there were only a hundred foreign literatures, which were rarely reported in China. The definition put forward by Huvos refers to "tumor cells that form irregular but anastomotic lumens in the tumor, with one or more layers of atypical endothelial cells as the border, and have anaplastic immature manifestations." Spjut proposed: "Angioendothelial sarcoma is a rare malignant tumor that originates from the vascular system cells or their precursor cells of bone. Endothelial cells have obvious tumor cell manifestations and have a tendency to form curved and anastomotic vessels." The disease accounts for 0.1% to 0.4% of bone tumors, 0.5% to 1% of malignant bone tumors, and 4.2% of primary spinal tumors. More men than women, the age of onset is 10 to 40 years old accounted for 70%. The disease is mostly single and occasionally multiple. Frequent sites are long bones of the limbs. The spine is rare, mainly in the thoracic, lumbar, and sacral vertebrae. Occasionally, cervical vertebrae are reported. Tumors are composed of bone vascular endothelial cells or mesenchymal cells that differentiate into endothelial cells. High degree of malignancy, rapid growth, lung metastases often occur earlier.