Skin bone marrow fibrosis

Cutaneous myelofibrosis, also known as cutaneous extramedullary hematopoiesis (CEH), is a chronic myeloproliferative disease characterized by clonal proliferation of defective pluripotent cells in the bone marrow. Overproduction and premature death of atypical megakaryocytes in the bone marrow produce a large number of platelet-derived growth factors, which is a powerful stimulator of fibroblast proliferation and collagen fiber production. Extramedullary hematopoiesis is a hallmark of myelofibrosis. Embryonic cells and committed stem cells escape from the bone marrow in large quantities, enter the blood circulation, and form the same atypical clonal tumor in other organs, especially the spleen, liver, and lymph nodes.