Neonatal diffuse intravascular coagulation

Disseminated intravascular coagulation (DIC) is an acquired hemorrhagic syndrome caused by many etiologies and occurring in many diseases. It is characterized by the body's coagulation system being activated under the action of certain pathogenic factors, the coagulation process is accelerated, fibrin deposition and platelet aggregation occur in the microcirculation, leading to extensive microthrombosis in blood vessels, and extensive bleeding occurs due to the consumption of coagulation factors . Due to the extensive formation of microthrombus in the microcirculation, tissue ischemia and hypoxia are caused, which affects important organ functions and even qualitative changes in the generator. Newborns have a higher incidence of DIC due to their susceptibility to serious diseases. The main clinical manifestations are extensive skin, mucosal and visceral bleeding, decreased blood pressure, shock and embolism.