Pyrimethamine poisoning

Pyrimidine is currently widely used as an antimalarial drug. Due to its large toxicity, the range between the amount of treatment and poisoning is small, and it is highly accumulative. Therefore, overdose or long-term application can easily lead to pyrimidin poisoning pyrimethaminepoisoning). When this product is taken orally up to 4 to 5 times the normal dosage, acute poisoning can occur. This medicine is slightly fragrant and slightly sweet, and children may mistakenly eat a lot of candy. Children take 25mg orally once per year, which can be fatal. This product can pass through the placental barrier and be secreted by the breast, and a large number of mothers mistakenly take adverse effects on the fetus and the baby.