Erythrocyte aggregation

Red blood cell aggregation reflects the ability of red blood cells to bind together. The factors that affect the aggregation of red blood cells are mainly as follows: ① The bridging force of macromolecules, that is, the binding between red blood cells cannot be a direct adhesion between red blood cell membranes, and there must be large molecules between the cells. "Bridge" and The aggregation of cells can be formed with the participation of calcium ions, etc. Therefore, the bridging force of macromolecules is the main force for cells to aggregate together. The more macromolecules, the stronger the aggregation of red blood cells. ②Electrostatic repulsive force & ldquo; The surface of red blood cell membrane is negatively charged, which is a kind of repulsive force for the aggregation of red blood cells. If certain factors reduce the surface charge of red blood cells (such as virus infection), the aggregation of red blood cells will increase. ③ The magnitude of shear stress: Shear stress is the force that red blood cells are subjected to when they are in motion. The shear stress is proportional to the shear rate. This force can disaggregate red blood cells. The greater the force, the more red blood cells will be. Not easy to form aggregates. ④ The morphology of red blood cells: The double-concave disc structure of normal red blood cells makes the cells have a large contact area, and it is easy for cells to aggregate. When the red blood cells deform the spherical or oval shape, the smaller the contact area with the cells, the weaker the aggregation force.