Cerebrospinal fluid lactate dehydrogenase

There are more than 20 known enzymes in normal cerebrospinal fluid, which are less than those in serum. The activity is far lower than that of serum. Most enzymes cannot penetrate the blood-brain barrier and are not affected by the level of serum enzyme activity, indicating that cerebrospinal fluid enzymes do not come from blood. The sources of cerebrospinal fluid enzymes and their mechanism of elevation under pathological conditions are as follows: changes in the permeability of the blood-brain barrier; release of enzymes in brain cells; disintegration of various cells in cerebrospinal fluid; release of enzymes in tumor cells; Increased; cerebrospinal fluid enzyme clearance decreased.