Septic kidney damage

During sepsis, the reactivity of vasoconstrictive substances (such as certain cytokines, platelet activating factors, endothelin and adenosine, etc.) in the body is increased, and the resulting hemodynamic changes and decreased renal blood flow are the causes of sepsis and renal failure One. In addition, there are also non-hemodynamic factors, such as bacteria that migrate to the kidneys with the blood and cause kidney infections. Renal biopsies in patients with sepsis renal failure have found microabscesses in the renal interstitium and tubules. .