Tumor VIP receptor imaging

Vasoactive intestinal peptide (VIP) is a neurotransmitter composed of 28 amino acids with multiple functions. It can regulate the proliferation and differentiation of normal and tumor cells through its receptors. VPAC (VIP receptor) is widely present in various normal and tumor tissues, but its expression density in tumor tissues is much higher than that in normal tissues, which lays the foundation for radionuclide-labeled vasoactive intestinal peptide receptor imaging. This imaging has been used in the diagnosis, staging, treatment options and prognosis evaluation of a variety of tumors.