Photosensitive skin damage

The clinical manifestations of hematoporphyria include abdominal pain, neuropsychiatric symptoms, and light-sensitive skin damage. Hematoporphyria was originally called purple disease, and it is a rare disease. Most of the diseases are caused by genetic defects caused by lack of enzymes in the heme synthesis pathway, which lead to disorders of porphyrin metabolism. Porphyrin precursors may be the material basis for abdominal and neuropsychiatric symptoms. The sympathetic nervous system plays a role in the pathogenesis of abdominal pain and increased blood pressure. According to the site of porphyrin metabolism disorder, it can be divided into erythropoietic hematoporphyria and hepatic hematoporphyria.